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Title   림프구의 종양에로의 이동에 관한 연구 - 진행위암과 결핵성능막염환자에서 세포성면역능의 비교 - ( Comparative Study of Immune Parameters in Advanced Gastric Cancer and Tuberculous Pleurisy )
Publicationinfo   1993 Jan; 025(03): 315-325.
Key_word   Natural killer cells, Stomach neoplasms, Tuberculosis
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Abstract   To evaluate the role of cellular immunity in the pathogenesis of advanced gastric cancer (AGC), the immunologic characteristics of tumor-associated lymphocytes in AGC were compared with those of lymphocytes in tuberculous pleurisy. The immune parameters of 57 metastatic gastric cancer patients were compared with those of 20 tuberculous pleurisy patients. 1) Natural ki11er(NK) activity in malignant ascites lymphocytes was lower than that in autologous peripheral blood 1ymphocytes(A-PBL) for advanced gastric carcinoma patients (p<0.01), In tuberculous patients, however, there was no difference between NK activity in pleural effusion and the activity in A-PBL. 2) Phenotypic analysis showed no significant difference in the proportion of A-PBL lympho- cytes between and ascites lymphocytes in AGC patients. In tuberculous patients, however, the proportion of lymphocytes expressing NK markers(CD16, CD56, and CD57) was significantly lower in the pleural effusion than in the A-PBL. 3) In gastric cancer, median survival was longer for patients with NK activity of PBL>50 lytic units(LU) than those with NK activity<50 LU(11 wks vs. 4 wks; p<0.01). This data suggests that the decreased NK activity in tumorassociated lymphocytes is not due to a blockage in migration of NK cells to the tumor site but is probably associated with the malfunction of NK cells under the influence of the tumor.
저 자   김노경(Noe Kyeong Kim),허대석(Dae Seog Heo),서창인(Chang In Suh),김영환(Young Whan Kim)